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Consultations and Updates to the List

Since the implementation of the Health (Pricing and Supply of Medical Goods) Act 2013, the Department of Health or HSE has directed the HPRA to assess the interchangeability of specified active substances.

The Act requires the HPRA to consult with relevant marketing authorisation holders prior to adding a medicine or a group of medicines to the list of interchangeable medicines.

Full details on the general consultation process and the possible outcomes can be found in our Guide to Interchangeable Medicines.

Details of ongoing and completed consultations, and resulting updates to the list of interchangeable medicines, are provided below:

Ongoing Consultations

The HPRA cannot comment or provide any further information on specific consultations.

The consultation process with the relevant marketing authorisation holders has commenced for the following active substances: 

  • Naproxen/Esomeprazole
  • Tamsulosin
  • Atorvastatin
  • Doxycycline
  • Ipratropium bromide
  • Nitrofurantoin
  • Mebeverine hydrochloride
  • Phenoxymethylpenicillin
  • Enalapril/Lercanidipine
  • Enalapril
  • Linezolid
  • Rivaroxaban
  • Amlodipine
  • Perindopril
  • Acetylsalicylic acid

The active substance will be included in the list, at a mutually agreed time, when the consultation is complete. 

Completed Consultations

The consultation process with the relevant marketing authorisation holders has been completed for each of the following active substances (most recently concluded first). The current version of the list includes all these active substances.

2025:

Teriflunomide

Fingolimod

Dabigatran

Imatinib

Dasatinib

Bosutinib

Ranolazine

Dimethyl fumarate 

2024:

Tapentadol

Azelastine/Fluticasone

Amoxicillin

Montelukast

Ezetimibe/Atorvastatin

Eplerenone

Esomeprazole

Losartan/Hydrochlorothiazide

Rosuvastatin

Valsartan

Alprazolam

Pomalidomide

Paliperidone

Alendronic acid/Cholecalciferol

Pirfenidone

Atorvastatin

Mirtazapine

Risperidone

Sitagliptin/Metformin

Quetiapine

Trazodone

Solifenacin succinate/Tamsulosin

Bisoprolol

Midodrine

Lercanidipine

Zopiclone

Isotretinoin

Irbesartan/Hydrochlorothiazide

Irbesartan

Rivastigmine

Desloratadine

Ulipristal

Celecoxib

Pramipexole

Fluconazole

Terbinafine

Icatibant

Sunitinib

Voriconazole

Ivabradine

Allopurinol

Ibandronic acid

Exemestane

Sumatriptan

Dutasteride

Salmeterol/Fluticasone

Modafinil

Fesoterodine

Bicalutamide

Apixaban

Sildenafil

Agomelatine

Ipratropium bromide/salbutamol

Escitalopram

Zolpidem

Cinacalcet

Deferasirox

Valaciclovir

Sitagliptin

Fulvestrant